Suite Hotels in Cape Girardeau, MO

Travel Guide | June 2025

Discover Luxury and Space in Cape Girardeau, MO Hotel Suites

Are you planning a visit to Cape Girardeau, MO and seeking accommodations that offer both comfort and ample space? Look no further than our selection of top-tier hotels with suites. Whether you're traveling for business, leisure, or a family getaway, these Cape Girardeau hotel suites provide the perfect blend of style, convenience, and relaxation.

Drury Inn & Suites Sikeston
Hotels
2608 East Malone Avenue, Sikeston, MO 63801, United States of America

Just off Interstate 55 and less than 3 miles from downtown Sikeston and Sikeston Depot, this Missouri hotel features a complimentary hot breakfast each morning. A modern fitness center is available on site. A microwave and a refrigerator are included in all rooms at the Drury Inn & Suites Sikeston. Free toiletries and ironing facilities are also provided in each guest room. Guests can enjoy a swim in the indoor-outdoor pool or relax in the hot tub at Drury Inn & Suites Sikeston. A laundromat and a 24-hour business center are also featured on site. Free snacks and beverages are served nightly. The Bootheel Golf Club is 3 miles from this hotel. Sikeston Factory Outlet Stores are less than a 2-minute drive away.

Suites:

  1. Queen Suite with Sofa Bed
  2. Superior Suite
  3. Superior King Suite
  4. Deluxe King Suite with Sofa Bed
  5. King Suite with Sofa Bed - Accessible, Tub
  6. Queen Suite with Sofa Bed - Accessible, Tub

Drury Plaza Hotel Cape Girardeau Conference Center
Hotels
3351 Percy Drive, Cape Girardeau, MO 63701, United States of America

Located in Cape Girardeau, Drury Plaza Hotel Cape Girardeau Conference Center provides a fitness center and free WiFi. This 3-star hotel offers a 24-hour front desk and an ATM machine. The hotel offers a hot tub and a business center. All rooms at the hotel are equipped with a seating area and a flat-screen TV with cable channels. Every room is equipped with a private bathroom with free toiletries. Guest rooms will provide guests with a desk. A buffet breakfast is served daily at the property. This property also provides a daily maid service. The wellness area of the property includes an indoor pool and a fitness center. Barkley Regional Airport is 47 mi from the property.

Suites:

  1. Deluxe King Suite
  2. Deluxe Queen Suite
  3. Superior King Suite
  4. Superior Suite
  5. King Suite with Sofa Bed - Hearing Accessible
  6. Queen Suite with Sofa Bed - Hearing Accessible
  7. Superior King Suite with Sofa Bed - Hearing Accessible, Tub
  8. Superior Queen Suite with Sofa Bed - Hearing Accessible, Tub

Drury Inn & Suites Jackson MO
Hotels
225 Drury Lane, Jackson, MO 63755, United States of America

Drury Inn & Suites Jackson MO is located in Jackson. Featuring a fitness center, the 3-star hotel has air-conditioned rooms with free WiFi, each with a private bathroom. The hotel features a hot tub and luggage storage space. At the hotel, rooms are equipped with a desk and a flat-screen TV. At Drury Inn & Suites Jackson MO every room has bed linen and towels. Free private parking and a business center are available, as well as a 24-hour front desk. The nearest airport is Cape Girardeau Regional Airport, 16 miles from the accommodation.

Suites:

  1. One-Bedroom Suite with Two Queen Beds
  2. King Suite
  3. Superior Suite
  4. Superior King Suite
  5. King Suite with Sofa Bed - Accessible, Tub

Courtyard by Marriott Cape Girardeau Downtown
Hotels
400 Broadway Street, Cape Girardeau, 63701, United States of America

Courtyard by Marriott Cape Girardeau Downtown features a fitness center, shared lounge, a restaurant and bar in Cape Girardeau. The 3-star hotel has air-conditioned rooms with a private bathroom and free WiFi. The property provides a 24-hour front desk and a business center for guests. Guest rooms in the hotel are equipped with a flat-screen TV and free toiletries. The nearest airport is Cape Girardeau Regional Airport, 6.8 miles from Courtyard by Marriott Cape Girardeau Downtown.

Suites:

  1. One-Bedroom King Suite with Sofa Bed

Drury Inn & Suites Cape Girardeau
Hotels
3303 Campster Drive, Cape Girardeau, MO 63701, United States of America

Drury Inn & Suites Cape Girardeau has accommodations in Cape Girardeau. This 3-star hotel offers luggage storage space. The hotel has a hot tub, a 24-hour front desk and free WiFi throughout the property. The rooms come with air conditioning, a flat-screen TV with cable channels, a fridge, a coffee machine, a shower, a hairdryer and a desk. Certain rooms come with a kitchenette with a microwave and a stovetop. The rooms at the hotel are equipped with a private bathroom and bed linen. Guests at Drury Inn & Suites Cape Girardeau can enjoy a buffet breakfast. A business center and a gym are available at the property as well as free private parking. The nearest airport is Cape Girardeau Regional Airport, 5.6 miles from the accommodation.

Suites:

  1. Queen Suite with Two Queen Beds
  2. King Suite
  3. Superior King Suite
  4. Superior Suite
  5. Queen Suite with Kitchen
  6. Superior Queen Suite with Kitchen
  7. King Suite with Sofa Bed - Accessible, Tub
  8. Superior Queen Suite with Sofa Bed - Accessible, Tub

Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
Hotels
3253 William Street, Cape Girardeau, MO 63701, United States of America

Located in Cape Girardeau, Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel has a casino. With a fitness center, the 2-star hotel has air-conditioned rooms with free WiFi, each with a private bathroom. Staff on site can arrange a shuttle service. At the hotel, every room is equipped with a desk and a flat-screen TV. At Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel the rooms are equipped with bed linen and towels. A business center and vending machines with snacks and drinks are available on site at the accommodation. Staff at Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel are always available to provide information at the reception. The nearest airport is Cape Girardeau Regional Airport, 5.6 miles from the hotel.

Suites:

  1. King Suite - Non-Smoking
  2. Queen Suite with Two Queen Beds and Sofa Bed
  3. Deluxe Suite
  4. Double Suite - Mobility Access Tub/Non-Smoking
  5. Suite with Two Queen Beds and Roll-in Shower - Communications Access
  6. King Suite with Hearing Accessible Roll In Shower - Non-Smoking

Fairfield by Marriott Inn & Suites Cape Girardeau
Hotels
433 Cape West Crossings, Cape Girardeau, 63703, United States of America

Fairfield by Marriott Inn & Suites Cape Girardeau has accommodations in Cape Girardeau. The hotel has an indoor pool, fitness center and a 24-hour front desk. A continental breakfast is available each morning at the hotel. The nearest airport is Cape Girardeau Regional Airport, 4.3 miles from Fairfield by Marriott Inn & Suites Cape Girardeau.

Suites:

  1. King Suite with Sofa Bed
  2. King Suite with Sofa Bed - Hearing Accessible

La Quinta Inn & Suites by Wyndham Jackson-Cape Girardeau
Hotels
3003 S Old Orchard Rd , Jackson, 63755, United States of America

Offering free WiFi throughout the property, La Quinta Inn & Suites by Wyndham Jackson-Cape Girardeau is located in Jackson. The hotel has an indoor pool, fitness center and a 24-hour front desk. At the hotel, the rooms include air conditioning and a private bathroom. The nearest airport is Cape Girardeau Regional Airport, 10 miles from La Quinta Inn & Suites by Wyndham Jackson-Cape Girardeau.

Suites:

  1. King Suite with Mobility Access and Bathtub with Grab Bars, Non-Smoking
  2. King Suite - Non-Smoking

Travel Inn and Suites- Sikeston Miner I-55 exit-67
Hotels
100 Matthews Lane, Sikeston, MO 63801, United States of America

Travel Inn and Suites- Sikeston Miner I-55 exit-67 is located in Sikeston. This 4-star motel offers room service, a 24-hour front desk and free WiFi. At the motel every room includes a desk and a flat-screen TV. The nearest airport is Cape Girardeau Regional Airport, 27 miles from Travel Inn and Suites- Sikeston Miner I-55 exit-67.

Suites:

  1. King Suite with Sofa Bed - Non-Smoking

Comfort Inn & Suites Sikeston I-55
Hotels
109 Matthews Lane, Sikeston, MO 63801, United States of America

Comfort Inn & Suites Sikeston I-55 is a 3-star property located in Sikeston. The hotel also provides free WiFi and free private parking. The nearest airport is Cape Girardeau Regional Airport, 27 miles from the hotel.

Suites:

  1. King Suite - Non-Smoking

Comfort Suites Jackson-Cape Girardeau
Hotels
2904 Old Orchard Road, Jackson, MO 63755, United States of America

Comfort Suites Jackson-Cape Girardeau is a 3-star property located in Jackson. The hotel features a fitness center, a 24-hour front desk and free WiFi throughout the property. At the hotel, every room includes a desk. All guest rooms at Comfort Suites Jackson-Cape Girardeau are equipped with a seating area and a TV with satellite channels. The accommodation offers a buffet or continental breakfast. The nearest airport is Cape Girardeau Regional Airport, 10 miles from Comfort Suites Jackson-Cape Girardeau.

Suites:

  1. King Suite - Non-Smoking
  2. Queen Suite with Two Queen Beds - Non-Smoking
  3. Suite with Two Queen Beds - Accessible/Non-Smoking
  4. King Suite with Accessible Tub - Accessible/Non-Smoking
  5. King Suite with Transfer Shower - Accessible/Non-Smoking

Days Inn and Suites by Wyndham Sikeston
Hotels
220 South Interstate Dr, Sikeston, 63801, United States of America

Days Inn and Suites by Wyndham Sikeston is a 2-star property located in Sikeston. The hotel has a fitness center, a 24-hour front desk and free WiFi throughout the property. At the hotel the rooms have air conditioning, a desk, a flat-screen TV, a private bathroom, bed linen, towels and a patio with a pool view. All rooms will provide guests with a closet and a coffee machine. Guests at Days Inn and Suites by Wyndham Sikeston can enjoy a continental breakfast. The nearest airport is Cape Girardeau Regional Airport, 27 miles from the accommodation.

Suites:

  1. Two-Bedroom Suite - Non-Smoking
  2. One-Bedroom Deluxe King Suite - Non-Smoking
  3. One-Bedroom King Suite - Non-Smoking
  4. One-Bedroom Deluxe Queen Suite - Non-Smoking
  5. One-Bedroom Suite with Two Queen Beds - Non-Smoking

Super 8 by Wyndham Sikeston/Miner Area
Hotels
2609 East Malone Avenue, Sikeston, MO 63801, United States of America

Super 8 by Wyndham Sikeston/Miner Area is located in Sikeston. With free WiFi, this 3-star hotel offers room service and a 24-hour front desk. The hotel features family rooms. All guest rooms features air conditioning, a fridge, a microwave, a coffee machine, a shower, a hairdryer and a desk. Complete with a private bathroom, the rooms at the hotel are equipped with a TV, and some rooms here will provide you with a seating area. The nearest airport is Cape Girardeau Regional Airport, 27 miles from Super 8 by Wyndham Sikeston/Miner Area.

Suites:

  1. Suite with Two Queen Beds - Non-Smoking

Country Yard Inn and Suites
Hotels
110 South Interstate Drive, Sikeston, MO 63801, United States of America

Country Yard Inn and Suites provides air-conditioned accommodations in Sikeston. This 2-star hotel offers a 24-hour front desk. The hotel also has free WiFi and free private parking. At the hotel, the rooms include a desk, a flat-screen TV, a private bathroom, bed linen and towels. All rooms will provide guests with a microwave. The nearest airport is Cape Girardeau Regional Airport, 27 miles from Country Yard Inn and Suites.

Suites:

  1. King Suite

Country Yard Inn and Suites
Hotels
110 South Interstate Drive, Sikeston, MO 63801, United States of America

Country Yard Inn and Suites provides air-conditioned accommodations in Sikeston. This 2-star hotel offers a 24-hour front desk. The hotel also has free WiFi and free private parking. At the hotel, the rooms include a desk, a flat-screen TV, a private bathroom, bed linen and towels. All rooms will provide guests with a microwave. The nearest airport is Cape Girardeau Regional Airport, 27 miles from Country Yard Inn and Suites.

Suites:

  1. King Suite

Most booked hotels with suites in Cape Girardeau

hotels with balcony in Cape Girardeau
2608 East Malone Avenue, Sikeston, MO 63801, United States of America
9.3
609 reviews
From $144
hotels with balcony in Cape Girardeau
100 Matthews Lane, Sikeston, MO 63801, United States of America
7.9
576 reviews
From $70
hotels with balcony in Cape Girardeau
3351 Percy Drive, Cape Girardeau, MO 63701, United States of America
9.3
453 reviews
From $126

Budget hotels with suites in Cape Girardeau

hotels with balcony in Cape Girardeau
2609 East Malone Avenue, Sikeston, MO 63801, United States of America
6.6
149 reviews
From $60
hotels with balcony in Cape Girardeau
110 South Interstate Drive, Sikeston, MO 63801, United States of America
6.3
20 reviews
From $65
hotels with balcony in Cape Girardeau
100 Matthews Lane, Sikeston, MO 63801, United States of America
7.9
576 reviews
From $70

Compare the Best Hotels with suites in Cape Girardeau – Addresses, Prices, Stars, Rating, and Review Count

Hotel Name Address Price ($) Star Rating Review Count Book
Drury Inn & Suites Sikeston 2608 East Malone Avenue, Sikeston, MO 63801, United States of America 144 3 9.3 609 Click here
Drury Plaza Hotel Cape Girardeau Conference Center 3351 Percy Drive, Cape Girardeau, MO 63701, United States of America 126 3 9.3 453 Click here
Drury Inn & Suites Jackson MO 225 Drury Lane, Jackson, MO 63755, United States of America 108 3 9.3 330 Click here
Courtyard by Marriott Cape Girardeau Downtown 400 Broadway Street, Cape Girardeau, 63701, United States of America 149 3 9.1 185 Click here
Drury Inn & Suites Cape Girardeau 3303 Campster Drive, Cape Girardeau, MO 63701, United States of America 142 3 9 358 Click here
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel 3253 William Street, Cape Girardeau, MO 63701, United States of America 129 2 8.8 322 Click here
Fairfield by Marriott Inn & Suites Cape Girardeau 433 Cape West Crossings, Cape Girardeau, 63703, United States of America 103 0 8.8 58 Click here
La Quinta Inn & Suites by Wyndham Jackson-Cape Girardeau 3003 S Old Orchard Rd , Jackson, 63755, United States of America 150 0 8.4 272 Click here
Travel Inn and Suites- Sikeston Miner I-55 exit-67 100 Matthews Lane, Sikeston, MO 63801, United States of America 70 4 7.9 576 Click here
Comfort Inn & Suites Sikeston I-55 109 Matthews Lane, Sikeston, MO 63801, United States of America 108 3 7.9 215 Click here
Comfort Suites Jackson-Cape Girardeau 2904 Old Orchard Road, Jackson, MO 63755, United States of America 87 3 7.6 212 Click here
Days Inn and Suites by Wyndham Sikeston 220 South Interstate Dr, Sikeston, 63801, United States of America 72 2 6.8 332 Click here
Super 8 by Wyndham Sikeston/Miner Area 2609 East Malone Avenue, Sikeston, MO 63801, United States of America 60 3 6.6 149 Click here
Country Yard Inn and Suites 110 South Interstate Drive, Sikeston, MO 63801, United States of America 65 2 6.3 20 Click here
Country Yard Inn and Suites 110 South Interstate Drive, Sikeston, MO 63801, United States of America 71 5 4 67 Click here

Note: The prices for each balcony hotels in Cape Girardeau do vary. This can be because of the number of people you are booking for, how far in advance you book and the season. The prices above are only meant as a rough estimate for comparison purposes. Click the buttons above (or click here) to get the latest prices.

Why Choose a Hotel Suite in Cape Girardeau, MO?

  1. Extra Space: Enjoy the luxury of separate living and sleeping areas, providing ample room to spread out and unwind.
  2. Enhanced Comfort: Experience elevated amenities and features designed to make your stay unforgettable.
  3. Ideal for Groups: Hotel suites accommodate families, friends, or business colleagues with ease.
  4. Prime Locations: Many Cape Girardeau hotel suites are located near popular attractions, shopping centers, and business districts.

Popular suite hotels in Cape Girardeau that have a pool include:

  • Drury Inn & Suites Sikeston.- Review Count: 609, Rating: 9.3
  • Drury Plaza Hotel Cape Girardeau Conference Center.- Review Count: 453, Rating: 9.3
  • Drury Inn & Suites Jackson MO.- Review Count: 330, Rating: 9.3

Transportation/Shuttle service is available at the following suite hotels in Cape Girardeau:

  • Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel.- Review Count: 322, Rating: 8.8

A spa is available to guests at the following suite hotels in Cape Girardeau:

  • Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel.- Review Count: 322, Rating: 8.8

Families traveling in Cape Girardeau enjoyed their stay at the following suite hotels:

  • Drury Inn & Suites Sikeston.- Review Count: 609, Rating: 9.3
  • Drury Plaza Hotel Cape Girardeau Conference Center.- Review Count: 453, Rating: 9.3
  • Drury Inn & Suites Jackson MO.- Review Count: 330, Rating: 9.3

These suite hotels in Cape Girardeau generally allow pets:

  • Drury Inn & Suites Sikeston.- Review Count: 609, Rating: 9.3
  • Drury Plaza Hotel Cape Girardeau Conference Center.- Review Count: 453, Rating: 9.3
  • Drury Inn & Suites Jackson MO.- Review Count: 330, Rating: 9.3

Free breakfast can be enjoyed at the following suite hotels in Cape Girardeau:

  • Courtyard by Marriott Cape Girardeau Downtown.- Review Count: 185, Rating: 9.1
  • Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel.- Review Count: 322, Rating: 8.8
  • Country Yard Inn and Suites.- Review Count: 67, Rating: 4

These suite hotels in Cape Girardeau have parking:

  • Drury Inn & Suites Sikeston.- Review Count: 609, Rating: 9.3
  • Drury Plaza Hotel Cape Girardeau Conference Center.- Review Count: 453, Rating: 9.3
  • Drury Inn & Suites Jackson MO.- Review Count: 330, Rating: 9.3

These 3 star hotels received great reviews from other travelers:

  • Drury Inn & Suites Sikeston.- Review Count: 609, Rating: 9.3
  • Drury Plaza Hotel Cape Girardeau Conference Center.- Review Count: 453, Rating: 9.3
  • Drury Inn & Suites Jackson MO.- Review Count: 330, Rating: 9.3

Some of the best suite hotels in Cape Girardeau are:

  • Country Yard Inn and Suites.- Review Count: 67, Rating: 4
  • Travel Inn and Suites- Sikeston Miner I-55 exit-67.- Review Count: 576, Rating: 7.9
  • Drury Inn & Suites Sikeston.- Review Count: 609, Rating: 9.3